Transgenic Gene Knockout Facility Back
Staff of Transgenic Geneknockout Facility

A National Facility for Transgenic and Gene Knock-out Mice sponsored by the Department of Science and Technology (DST), Government of India has been set up at the CCMB with the following aims: 

  • Procurement and maintenance of transgenic and knock-out mouse models of human diseases where such animals are available elsewhere without restriction and provide facility and expertise to use the same in drug screening. 

  • Breeding of currently available transgenic and knock-out mouse models. 

  • Development of transgenic and gene knock-out technologies.

  • Development of new transgenic and gene knock-out mice models of human diseases. 

A modern Mouse Facility houses transgenic mice and other experimental mouse strains needed for creation of Transgenic and Gene Knock-out mice. Mouse Genetics Laboratory includes well-furnished infrastructure for culture of Embryonic Stem Cells, Cryopreservation of Embryos, Micro-manipulation of Embryos, Animal Surgery, Construction of Transgenes & Gene Knock-out Vectors, Identification of Transgenic & Knock-out Mice, and Analysis of Gene Expression.

We are routinely using microinjection of DNA into mouse eggs and genetic manipulation of mouse embryonic stem cells to create Transgenic & Gene Knockout Mice for understanding of regulation of gene expression and for delineating the function of mammalian genes through in-house research projects and by collaborating with other organizations.

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